meso-Tetrakis(p-sulfonatophenyl)N-Confused Porphyrin Tetrasodium Salt: A Potential Sensitizer for Photodynamic Therapy

Please use this identifier to cite or link to this item: http://idr.niser.ac.in:8080/jspui/handle/123456789/991

Title:	meso-Tetrakis(p-sulfonatophenyl)N-Confused Porphyrin Tetrasodium Salt: A Potential Sensitizer for Photodynamic Therapy
Authors:	Thomas, Ajesh P. Chandrashekar, Tavarekere Kalliah Srinivasan, Alagar
Keywords:	Apoptosis Cells Fluorescence Pyrroles Reaction products
Issue Date:	14-May-2012
Publisher:	Journal of Medicinal Chemistry
Citation:	Thomas, A. P., Saneesh Babu, P. S., Asha Nair, S., Ramakrishnan, S., Ramaiah, D., Chandrashekar, T. K., … Radhakrishna Pillai, M. (2012). Meso-tetrakis(p-sulfonatophenyl)N-confused porphyrin tetrasodium salt: a potential sensitizer for photodynamic therapy. Journal of Medicinal Chemistry, 55(11), 5110–5120.
Abstract:	A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC50 values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques.
URI:	https://doi.org/10.1021/jm300009q http://idr.niser.ac.in:8080/jspui/handle/123456789/991
Appears in Collections:	Journal Papers

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