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dc.contributor.authorGoswami, Chandan-
dc.date.accessioned2024-12-02T11:38:34Z-
dc.date.available2024-12-02T11:38:34Z-
dc.date.issued2013-11-01-
dc.identifier.citationKumar, A., Bhandari, A., Sarde, S. J., & Goswami, C. (2013). Sequence, phylogenetic and variant analyses of antithrombin III. Biochemical and Biophysical Research Communications, 440(4), 714–724.en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2013.09.134-
dc.identifier.urihttp://idr.niser.ac.in:8080/jspui/handle/123456789/1062-
dc.description.abstractAntithrombin III (ATIII) performs a critical anticoagulant function by precluding the activation of blood clotting proteinases, aided by its two cofactors, heparin and heparan sulfate. Though several studies have been carried out on physiological, biochemical and structural perspectives on ATIII, so far there are lim ited studies on the molecular evolution of ATIII. Herein, we carried out molecular phylogenetic analyses of ATIII genes, combining gene structures, synteny and sequence-structural features for ATIII spanning 50 vertebrate genomes. ATIII is maintained over 450 MY on same genomic loci in vertebrates with few changes in ray-finned fishes and lost one intron 262c in tetrapods and coelacanth. In ray-finned fishes, ATIII gene has additional intron at the position 262c, which shared by group V1 members, corroborating that it is lost in other vertebrates and also in lobed-finned fish coelacanth (Latimeria chalumnae). We found that heparin binding basic residues, hD helix, three pairs of Cys–Cys salt bridges, N-glycosylation sites, serpin motifs and inhibitory reactive center loop (RCL) of ATIII protein are highly conserved. Using 1092 humangenomes available from 1000G project, we also compiled 1997 ATIII variants, which reveals 76.2% single nucleotide polymorphisms (SNPs), 11.8% deletions and 8.1% insertions as three major classes of gene variations. These understandings may have medical importance as well.en_US
dc.language.isoenen_US
dc.publisherBiochemical and Biophysical Research Communicationsen_US
dc.subjectAntithrombin IIIen_US
dc.subjectSerpinC1en_US
dc.subjectGroup V5en_US
dc.subjectSyntenyen_US
dc.subjectPhylogenetic analysisen_US
dc.subjectATIII variantsen_US
dc.titleSequence, phylogenetic and variant analyses of antithrombin IIIen_US
dc.typeArticleen_US
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