Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents

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DC Field	Value	Language
dc.contributor.author	Konkimalla, V. Badireenath	-
dc.date.accessioned	2024-11-25T15:02:05Z	-
dc.date.available	2024-11-25T15:02:05Z	-
dc.date.issued	2011-11-30	-
dc.identifier.citation	Malwal, S. R., Sriram, D., Yogeeswari, P., Konkimalla, V. B., & Chakrapani, H. (2012). Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents. Journal of Medicinal Chemistry, 55(1), 553–557.	en_US
dc.identifier.uri	https://doi.org/10.1021/jm201023g	-
dc.identifier.uri	http://idr.niser.ac.in:8080/jspui/handle/123456789/1009	-
dc.description.abstract	Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 μM) of inhibiting Mycobacterium tuberculosis (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 μM).	en_US
dc.language.iso	en	en_US
dc.publisher	Journal of Medicinal Chemistry	en_US
dc.subject	Amines	en_US
dc.subject	Group 16 compounds	en_US
dc.subject	Inhibition	en_US
dc.subject	Oxides	en_US
dc.subject	Thiols	en_US
dc.title	Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents	en_US
dc.type	Article	en_US
Appears in Collections:	Journal Papers

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