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http://idr.niser.ac.in:8080/jspui/handle/123456789/1009| Title: | Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents |
| Authors: | Konkimalla, V. Badireenath |
| Keywords: | Amines Group 16 compounds Inhibition Oxides Thiols |
| Issue Date: | 30-Nov-2011 |
| Publisher: | Journal of Medicinal Chemistry |
| Citation: | Malwal, S. R., Sriram, D., Yogeeswari, P., Konkimalla, V. B., & Chakrapani, H. (2012). Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents. Journal of Medicinal Chemistry, 55(1), 553–557. |
| Abstract: | Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 μM) of inhibiting Mycobacterium tuberculosis (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 μM). |
| URI: | https://doi.org/10.1021/jm201023g http://idr.niser.ac.in:8080/jspui/handle/123456789/1009 |
| Appears in Collections: | Journal Papers |
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