An Intracameral Injection of Antigen Induces In Situ Chemokines and Cytokines Required for the Generation of Circulating Immunoregulatory Monocytes See

Anterior Chamber-Associated Immune Deviation (ACAID) induced by an intracameral injection of antigen generates antigen-specific regulatory splenic T cells that suppress specifically cell-mediated immunity specific for the injected antigen. Circulating F4/80+ cells recovered from mice receiving an intracameral injection of antigen are thought to be ocular in origin and induce the development of thymic and splenic regulatory T cells. We have shown previously that after the intracameral injectio...

Tuning Cooperativity by Controlling the Linker Length of Silica-Supported Amines in Catalysis and CO2 Capture See

Cooperative interactions between aminoalkylsilanes and silanols on a silica surface can be controlled by varying the length of the alkyl linker attaching the amine to the silica surface from C1 (methyl) to C5 (pentyl). The linker length strongly affects the catalytic cooperativity of amines and silanols in aldol condensations as well as the adsorptive cooperativity for CO2 capture. The catalytic cooperativity increases with the linker length up to propyl (C3), with longer, more flexible linke...

Trideuteriomethoxylation of Aryl and Heteroaryl Halides See

Direct access to trideuteriomethoxylated aromatic and het-eroaromatic compounds has been developed. Various aryland heteroaryl halides underwent d3-methoxylation undermild reaction conditions by using a catalyst system composed of the commercially available monodentate phosphane li-gandtBuXPhos and Pd(OAc)2. Inexpensive CD3OD servedas an efficient trideuteriomethoxylating agent.

On the high performance of channel photonic crystal waveguide comprising different plasmonic active metals See

We present a detailed design principle and the propagation characteristics of a channel photonic-crystal-surface-plasmon waveguide (PCSPW), comprised of silica- photonic crystal waveguide (PCW) and plasmonic waveguide based on different plasmonic active metals such as gold (Au), silver (Ag) and aluminium (Al). We found that the phase-matching/resonance wavelength can be substantially tuned over a broad spectral range by judiciously choosing different plasmonic metals. The Al-based channel PCS...

Polymeric Modification and Its Implication in Drug Delivery: Poly-ε-caprolactone (PCL) as a Model Polymer See

Biodegradable polymers provided the opportunity to explore beyond conventional drug delivery and turned out to be the focus of current drug delivery. In spite of availability of diverse class of polymers, several of these polymers lack important physicochemical and biological properties, limiting their widespread application in pharmaceutical drug delivery. However, most polymers in the form of blends, copolymers and functionally modified polymers have exhibited their applicability to overcom...

Ruthenium Catalyzed Hydroboration of Terminal Alkynes to Z-Vinylboronates See

The nonclassical ruthenium hydride pincer complex [Ru(PNP)(H)2(H2)] 1 (PNP = 1,3-bis(di-tert-butyl-phosphinomethyl)pyridine) catalyzes the anti-Markovnikov addition of pinacolborane to terminal alkynes yielding Z-vinylboronates at mild conditions. The complex [Ru(PNP)(H)2(HBpin)] 2 (HBpin = pinacolborane), which was identified at the end of the reaction and prepared independently, is proposed as the direct precursor to the catalytic cycle involving rearrangement of coordinated alkyne to Z-vin...

Half-metallicity in graphene nanoribbons with topological defects at edge See

We report first principles studies of zigzag edged graphene nanoribbons (ZGNR) with one edge partially covered by topological defects. With increasing coverage of an edge by pentagons and heptagons, which are two of the simplest topological defects possible in a graphenic lattice, ZGNRs evolve from a magnetic semiconductor to a ferromagnetic metal. This evolution can be intermediated by a narrow bandgap half-metallic phase, upon suitable concentration and conformation of defects at the edge. ...

Photophysical and density functional studies on the interaction of a new nitrobenzoxadiazole derivative with anions See

Photophysical and density functional studies on a nitrobenzoxadiazole-based system, N-butyl-7-nitrobenzo[c] [1,2,5]oxadiazol-4-amine (NBDH), have been investigated with a view to obtain molecular level understanding of the mechanism of interaction of inorganic anions with NBDH. The emission spectrum of the system exhibits large quenching of fluorescence on addition of F−. No appreciable changes in the absorption and fluorescence behavior of the present systems have been found in the presence ...

Effects of Psychological Stress on Innate Immunity and Metabolism in Humans: A Systematic Analysis See

Stress is perhaps easiest to conceptualize as a process which allows an organism to accommodate for the demands of its environment such that it can adapt to the prevailing set of conditions. Psychological stress is an important component with the potential to affect physiology adversely as has become evident from various studies in the area. Although these studies have established numerous effects of psychological stress on physiology, a global strategy for the correlation of these effects ha...